The presentation of regioselectivity of 1-ethyl-3-[4-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-а]azepin-3-yl)phenyl]thiourea cyclization with α-bromoketone
نویسندگان
چکیده
منابع مشابه
Syntheses of 11-substituted 3-methyl-3,4,10,11-tetrahydro-1H,5H-pyrano[4, 3-b][1,5]benzodiazepin-1-ones.
In the course of our synthetic studies on biologically active compounds using dimedone, tetronic acids, and tetramic acids,1) we reported that some 10-substituted 3,3-dimethyl3, 4, 9, 10tetrahydro1Hfuroand -pyrrolo [4, 3-b] [1, 5] benzodiazepin1-ones (1 and 2) showed analgesic activity as strong as that of aminopyrine in the phenylquinone writhing test in mice.2) Namely, the extents of inhibiti...
متن کاملEthyl 3-[1-(4-bromophenyl)ethylidene]carbazate
In the crystal of the title compound, C(10)H(11)BrN(2)O(2), the mol-ecules are linked by N-H⋯O hydrogen bonds, forming S(4) chains propagating in [100]. A C-H⋯O inter-action also occurs.
متن کاملEthyl 4-[3-(1H-imidazol-1-yl)propylamino]-3-nitrobenzoate
In the title compound, C(15)H(18)N(4)O(4), the 1H-imidazole ring forms a dihedral angle of 67.12 (8)° with the benzene ring. An S(6) ring motif is formed via an intra-molecular N-H⋯O hydrogen bond. In the crystal, neighbouring mol-ecules are linked by a pair of inter-molecular N-H⋯N hydrogen bonds, forming an inversion dimer. The dimers are further linked by a pair of C-H⋯O hydrogen bonds, lead...
متن کاملEthyl 1-(4-methoxyphenyl)-2-nitro-3-[4-oxo-3-phenyl-1-(4-methoxyphenyl)azetidin-2-yl]-2,3,10,10a-tetrahydro-1H,5H-pyrrolo[1,2-b]isoquinoline-10a-carboxylate
In the mol-ecule of the title compound, C(38)H(37)N(3)O(7), the pyrrolidine ring adopts a twist conformation and the six-membered heterocyclic ring has a boat conformation. In the crystal structure, mol-ecules are linked into a three-dimensional framework through inter-molecular C-H⋯O hydrogen bonds. One ethyl group is disordered over two positions with occupancies 0.67 (2)/0.33 (2).
متن کاملEthyl 1-(4-chlorophenyl)-3-[1-(4-methoxyphenyl)-4-oxo-3-phenylazetidin-2-yl]-2-nitro-2,3,10,10a-tetrahydro-1H,5H-pyrrolo[1,2-b]isoquinoline-10a-carboxylate
In the title compound, C(37)H(34)ClN(3)O(6), the pyrrolidine and piperidine rings adopt envelope and boat conformations, respectively. The β-lactam ring is planar and forms dihedral angles of 21.3 (2) and 73.9 (2)°, respectively, with the attached methoxy-phenyl and phenyl rings. Intra-molecular C-H⋯O and C-H⋯N hydrogen bonds are observed. Centrosym-metrically related mol-ecules are linked toge...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Organic and Pharmaceutical Chemistry
سال: 2017
ISSN: 2518-1548,2308-8303
DOI: 10.24959/ophcj.17.916